| Identification | Back Directory | [Name]
5-(4-methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine | [CAS]
342595-74-8 | [Synonyms]
UMK57
5-(4-methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine | [Molecular Formula]
C17H17N3S | [MOL File]
342595-74-8.mol | [Molecular Weight]
295.4 |
| Chemical Properties | Back Directory | [Boiling point ]
492.5±45.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.35±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
UMK57 is a novel inhibitor of chromosomal instability, potentiating MCAK in vivo and transiently suppressing chromosome mis-segregation in CIN cancer cells. | [Uses]
UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1]. | [References]
[1] Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763. |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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