| Identification | Back Directory | [Name]
LM22B-10 | [CAS]
342777-54-2 | [Synonyms]
LM22B-10
2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
Ethanol, 2,2',2'',2'''-[[(4-chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis-
2-[[4-[[4-[BIS-(2-HYDROXYETHYL)-AMINO]-PHENYL]-(4-CHLORO-PHENYL)-METHYL]-PHENYL]-(2-HYDROXY-ETHYL)-AMINO]-ETHANOL | [Molecular Formula]
C27H33ClN2O4 | [MDL Number]
MFCD00483554 | [MOL File]
342777-54-2.mol | [Molecular Weight]
485.01 |
| Chemical Properties | Back Directory | [Boiling point ]
718.9±60.0 °C(Predicted) | [density ]
1.287±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
14.00±0.10(Predicted) | [color ]
Light green to green | [InChIKey]
QCXQLSGBOUUVNH-UHFFFAOYSA-N | [SMILES]
ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1 |
| Hazard Information | Back Directory | [Uses]
LM22B-10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant. | [Biological Activity]
LM22B-10 is a brain penetrantpotent and selective TrkB and TrkC neurotrophin receptors agonist th at improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells. | [in vivo]
LM22B-10 (0.5 mg/kg) activates TrkB, TrkC, AKT and ERK in C57BL/6J mice. LM22B-10 (50 mg/kg, i,p,) shows increased phosphorylation at TrkBY817 and TrkCY820. LM22B-10 activates synaptic TrkB and TrkC and increases pre- and post-synaptic proteins and spine density in aged mice[1]. | [IC 50]
TrkB; TrkC; ERK; Akt | [storage]
Store at -20°C |
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