| Chemical Properties | Back Directory | [density ]
1.60±0.1 g/cm3(Predicted) | [pka]
3.21±0.10(Predicted) | [Sequence]
H-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH(Disulfide bonds, air oxidized) |
| Hazard Information | Back Directory | [Uses]
Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains[1][2][3]. | [References]
[1] Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280(12):2842-54. DOI:10.1111/febs.12288
[2] Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57(9):4314-4321. DOI:10.1128/AAC.00904-13
[3] Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30(4):435-46. DOI:10.1080/08927014.2014.888062 |
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