| Identification | Back Directory | [Name]
3,9-Diazabicyclo[3.3.1]nonane, 9-methyl-3-(2-phenyldiazenyl)- | [CAS]
3431-16-1 | [Synonyms]
VEC6
VEC-6
VEC 6
NSC11435
NSC-11435
NSC 11435
3,9-Diazabicyclo[3.3.1]nonane, 9-methyl-3-(2-phenyldiazenyl)- | [Molecular Formula]
C14H20N4 | [MOL File]
3431-16-1.mol | [Molecular Weight]
244.34 |
| Hazard Information | Back Directory | [Description]
VEC6 is an inhibitor of VEZF1–DNA interaction that recapitulates RhoB loss in ischaemic retinopathy. | [Uses]
VEC6 (NSC 11435) is an inhibitor of VEZF1–DNA interaction and has the activity to recapitulate RhoB loss in ischemic retinopathy. VEC6 reduces pathological angiogenesis and promotes lymphangiogenesis. VEC6 plays a unique role in angiogenesis and lymphangiogenesis by regulating the expression of different sets of genes in endothelial cells. VEC6 has an inhibitory effect on VEZF1-mediated transcriptional activity, thereby affecting the proliferation and sprouting of endothelial cells[1]. | [References]
[1] RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription DOI:10.1038/ncomms3824 |
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