| Identification | Back Directory | [Name]
BMS-394136
(BMS394136) | [CAS]
343246-73-1 | [Synonyms]
BMS-394136
UNII-M694U7167K
BMS-394136
(BMS394136)
Methanone, [(7R)-7-(3,4-dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl][(2S)-2-(4-fluorophenyl)-1-pyrrolidinyl]- | [Molecular Formula]
C24H21Cl2FN4O | [MOL File]
343246-73-1.mol | [Molecular Weight]
471.35 |
| Hazard Information | Back Directory | [Uses]
BMS-394136 (compound 1) is a potent inhibitor of Kv 1.5, with an IC50 of 0.05 μM. BMS-394136 is a selective IKur inhibitor. BMS-394136 dose-dependently prolongs atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP). BMS-394136 can be used for acute atrial ischemia research[1]. | [References]
[1] Gunaga P, et al. Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60(9):3795-3803. DOI:10.1021/acs.jmedchem.6b01889
[2] Dezhi Xing, et al. Abstract 12964: Acute Atrial Ischemia Increases the Activity of BMS-394136, a Selective IKur Inhibitor, on Atrial Refractoriness and APD. Originally published 23 Mar 2018. Circulation. 2010;122:A12964. |
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