| Identification | Back Directory | [Name]
DH 97 | [CAS]
343263-95-6 | [Synonyms]
DH 97
N-PENTANOYL-2-BENZYLTRYPTAMINE
N-[2-(2-benzyl-1H-indol-3-yl)ethyl]pentanamide
1-Pentanone,1-[3-(2-aminoethyl)-2-(phenylmethyl)-1H-indol-1-yl]- | [Molecular Formula]
C22H26N2O | [MDL Number]
MFCD02262121 | [MOL File]
343263-95-6.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [Boiling point ]
488.6±35.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [pka]
9.53±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
DH 97 is an antagonist of melatonin receptor 2 (MT2; Kis = 252 and 1,100 for human MT2 and MT1 receptors, respectively). | [Uses]
DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively[1]. | [Definition]
ChEBI: N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]pentanamide is a member of indoles. | [Biological Activity]
A relatively potent MT 2 melatonin receptor antagonist (pK i value = 8.03), displaying 89- and 229-fold selectivity over MT 1 and GPR50 (melatonin-related orphan receptor) respectively. | [IC 50]
MT2: 252 nM (Ki); MT1: 1100 nM (Ki) | [References]
[1] O Nosjean, et al. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2. Biochem Pharmacol. 2001 Jun 1;61(11):1369-79. DOI:10.1016/s0006-2952(01)00615-3 |
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