| Identification | Back Directory | [Name]
2-Pentenoic acid, 4-[[(2S)-2-[3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo-4-pentyn-1-yl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-, ethyl ester, (2E,4S)- | [CAS]
343565-99-1 | [Synonyms]
AG7404
AG-7404
AG 7404
2-Pentenoic acid, 4-[[(2S)-2-[3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo-4-pentyn-1-yl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-, ethyl ester, (2E,4S)- | [Molecular Formula]
C26H29N5O7 | [MDL Number]
MFCD32204766 | [MOL File]
343565-99-1.mol | [Molecular Weight]
523.54 |
| Chemical Properties | Back Directory | [Boiling point ]
924.2±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Solid | [pka]
9?+-.0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AG-7404 is an inhibitor of picornaviral 3C protease, with anti-poliovirus activity (EC50=0.080-0.674 μM). AG-7404 has synergy with V-073 (HY-104074) or BTA798 (HY-106254), and fully inhibits all V-073-resistant variants[1]. AG-7404 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Rhoden E,et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98(2):186-91. DOI:10.1016/j.antiviral.2013.03.003 |
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