| Identification | Back Directory | [Name]
(2E)-3-(1H-Imidazole-4-yl)propenoic acid | [CAS]
3465-72-3 | [Synonyms]
Chebi:30817
Trans-uric acid
(E)-Urocanic acid
trans-Urocanic acid
trans-UrocanicAcid>
Thiamazole Impurity 5
trans-Urocanic Acid
(E)-3-(4-Imidazolyl)acrylic acid
(αE)-1H-Imidazole-4-acrylic acid
(2E)-3-(1H-Imidazol-4-yl)acrylic acid
(2E)-3-(1H-Imidazole-4-yl)acrylic acid
(E)-3-(1H-Imidazol-4-yl)propenoic acid
transUrocanic Acid,trans Urocanic Acid
(2E)-3-(1H-Imidazole-4-yl)propenoic acid
(2E)-3-(1H-Imidazol-4-yl)prop-2-enoic acid
2-Propenoic acid, 3-(1H-imidazol-5-yl)-, (2E)- | [EINECS(EC#)]
203-258-4 | [Molecular Formula]
C6H6N2O2 | [MDL Number]
MFCD00005203 | [MOL File]
3465-72-3.mol | [Molecular Weight]
138.12 |
| Chemical Properties | Back Directory | [Melting point ]
225 °C | [Boiling point ]
456.9±20.0 °C(Predicted) | [density ]
1.430±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 3 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 0.3 mg/ml | [form ]
powder to crystal | [pka]
3.55±0.10(Predicted) | [color ]
White to Almost white |
| Hazard Information | Back Directory | [Uses]
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function[1]. | [Definition]
ChEBI: The trans-isomer of urocanic acid. | [IC 50]
Human Endogenous Metabolite | [References]
[1] J Uksila, et al. Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitro. Exp Dermatol. 1994 Apr;3(2):61-5. DOI:10.1111/j.1600-0625.1994.tb00048.x
[2] Kazuyo Kaneko, et al. cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes. J Invest Dermatol. 2011 Jun;131(6):1262-71. DOI:10.1038/jid.2011.37 |
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TCI AMERICA
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800-4238616 |
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