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346673-06-1

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346673-06-1 Structure

346673-06-1 Structure
IdentificationBack Directory
[Name]

(5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone
[CAS]

346673-06-1
[Synonyms]

TCS 2510
CAY10598
(5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone
[Molecular Formula]

C21H29N5O2
[MDL Number]

MFCD18384961
[MOL File]

346673-06-1.mol
[Molecular Weight]

383
Chemical PropertiesBack Directory
[Boiling point ]

632.0±65.0 °C(Predicted)
[density ]

1.238±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
[form ]

Powder
[pka]

5.07±0.10(Predicted)
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Flame (GHS02)Health Hazard (GHS08)
GHS02,GHS08
[Signal word ]

Danger
[Hazard statements ]

H225-H350
[Precautionary statements ]

P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501
Hazard InformationBack Directory
[Uses]

TCS 2510 is a selective agonist of EP4.
[in vivo]

TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]

Animal Model:Mice[1]
Dosage:0.1~10 mg/kg
Administration:P.o.
Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
Animal Model:Mice[1]
Dosage:10 mg/kg
Administration:P.o.
Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
Animal Model:Mice[1]
Dosage:1~10 mg/kg
Administration:P.o.
Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
[storage]

Store at -20°C
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