| Identification | Back Directory | [Name]
(5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone | [CAS]
346673-06-1 | [Synonyms]
TCS 2510
CAY10598
(5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone | [Molecular Formula]
C21H29N5O2 | [MDL Number]
MFCD18384961 | [MOL File]
346673-06-1.mol | [Molecular Weight]
383 |
| Chemical Properties | Back Directory | [Boiling point ]
632.0±65.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) | [form ]
Powder | [pka]
5.07±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
TCS 2510 is a selective agonist of EP4. | [in vivo]
TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1] | Animal Model: | Mice[1] | | Dosage: | 0.1~10 mg/kg | | Administration: | P.o. | | Result: | Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
|
| Animal Model: | Mice[1] | | Dosage: | 10 mg/kg | | Administration: | P.o. | | Result: | Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels. |
| Animal Model: | Mice[1] | | Dosage: | 1~10 mg/kg | | Administration: | P.o. | | Result: | Afforded a significant elevation in plasma glucagon like peptide 2 levels. |
| [storage]
Store at -20°C |
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