| Identification | Back Directory | [Name]
LTV-1 | [CAS]
347379-29-7 | [Synonyms]
LTV-1
CS-2057
CAS 347379-29-7
3-[[4-[(E)-[1-(2-methylphenyl)-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene]methyl]phenoxy]methyl]benzoic acid
Benzoic acid, 3-[[4-[[tetrahydro-1-(2-methylphenyl)-4,6-dioxo-2-thioxo-5(2H)-pyrimidinylidene]methyl]phenoxy]methyl]- | [Molecular Formula]
C26H20N2O5S | [MDL Number]
MFCD02219012 | [MOL File]
347379-29-7.mol | [Molecular Weight]
472.51 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 83.3 mg/mL (176.29 mM) | [form ]
Solid | [pka]
4.14±0.10(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment[1]. | [storage]
Store at -20°C | [References]
[1] Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8(5):437-446. DOI:10.1038/nchembio.916 |
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