ChemicalBook--->CAS DataBase List--->348-65-2

348-65-2

348-65-2 Structure

348-65-2 Structure
IdentificationBack Directory
[Name]

5-Chloro-2,4-Difluoroaniline
[CAS]

348-65-2
[Synonyms]

5-Chloro-2,4-Difluoroaniline
Aniline, 5-chloro-2,4-difluoro-
2,4 - difluoro -5- chloroaniline
5-Chloro-2,4-Difluoroaniline,>98%
Benzenamine, 5-chloro-2,4-difluoro-
1-Amino-5-chloro-2,4-difluorobenzene
5-Chloro-2,4-Difluoroaniline ISO 9001:2015 REACH
[Molecular Formula]

C6H4ClF2N
[MDL Number]

MFCD06808806
[MOL File]

348-65-2.mol
[Molecular Weight]

163.55
Chemical PropertiesBack Directory
[Melting point ]

50-51 °C(Solv: ligroine (8032-32-4))
[Boiling point ]

218.7±35.0 °C(Predicted)
[density ]

1.459±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[pka]

2.21±0.10(Predicted)
[Appearance]

Off-white to gray Solid
[InChI]

InChI=1S/C6H4ClF2N/c7-3-1-6(10)5(9)2-4(3)8/h1-2H,10H2
[InChIKey]

IKDJKRZDCUNAAB-UHFFFAOYSA-N
[SMILES]

C1(N)=CC(Cl)=C(F)C=C1F
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2921420090
Hazard InformationBack Directory
[Chemical Properties]

5-Chloro-2,4-difluoroaniline is a halogenated aniline analog, which contains an amino unit and a chlorine atom in its structure, and exhibits abundant chemical transformation activities. Firstly, the amino group in the structure of aniline can undergo cross-coupling reaction with aryl halogenated compounds catalyzed by metallic palladium, and can also undergo condensation reaction with carboxylic acids to obtain the corresponding amide derivatives under the action of condensation agents. In addition, the fluorine atom on the benzene ring in the structure of 5-chloro-2,4-difluoroaniline can be defluorinated under the attack of strong nucleophilic reagents.
[Uses]

5-Chloro-2,4-difluoroaniline can be used as reactant/reagent in preparation of aminoisoxazoline compds. as agonists of α7-nicotinic acetylcholine receptors.
Spectrum DetailBack Directory
[Spectrum Detail]

5-Chloro-2,4-Difluoroaniline(348-65-2)1HNMR
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