| Identification | Back Directory | [Name]
2-Propen-1-one, 1,1'-(1,4-phenylene)bis[3-(3-pyridinyl)- | [CAS]
348145-43-7 | [Synonyms]
2-Propen-1-one, 1,1'-(1,4-phenylene)bis[3-(3-pyridinyl)- | [Molecular Formula]
C22H16N2O2 | [MOL File]
348145-43-7.mol | [Molecular Weight]
340.37 |
| Chemical Properties | Back Directory | [Boiling point ]
573.1±50.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 0.5mg/mL, clear (Warmed) | [form ]
powder | [pka]
4.44±0.12(Predicted) | [color ]
white to beige | [InChIKey]
IOESTAVFGVAMRH-YDWXAUTNSA-N | [SMILES]
O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2 |
| Hazard Information | Back Directory | [Uses]
POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors[1]. | [Biological Activity]
Mitochondrial fission inhibitor th at blocks DRP1 recruitment to mitochondria.
DRP1 Inhibitor MIDI is a cell-permeablesymmetrical pyridinyl-propenone compound th at acts as a potenttime-dependent mitochondrial fission inhibitor (0.5 - 2 μM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity. | [References]
[1] Jun Yang, et al. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chem Biol. 2023 Mar 16;30(3):278-294.e11. DOI:10.1016/j.chembiol.2023.02.002 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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