| Identification | Back Directory | [Name]
Ceefourin 2 | [CAS]
348148-51-6 | [Synonyms]
Ceefourin 2
Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid, 3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)- | [Molecular Formula]
C15H9ClF3N3O2 | [MOL File]
348148-51-6.mol | [Molecular Weight]
355.7 |
| Hazard Information | Back Directory | [Description]
Ceefourin-2 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4). | [Uses]
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1]. | [References]
[1] Cheung L, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol. 2014 Sep 1;91(1):97-108. DOI:10.1016/j.bcp.2014.05.023 |
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Abcam Limited
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021-2070050 400921018 |
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www.abcam.cn |
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