| Identification | Back Directory | [Name]
BURIMAMIDE OXALATE | [CAS]
34970-69-9 | [Synonyms]
Burimamide
BURIMAMIDE OXALATE
N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthiourea
Thiourea, N-[4-(1H-imidazol-5-yl)butyl]-N'-methyl-
N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthioureaoxalate | [Molecular Formula]
C9 H16 N4 S | [MDL Number]
MFCD09038550 | [MOL File]
34970-69-9.mol | [Molecular Weight]
212.32 |
| Chemical Properties | Back Directory | [Boiling point ]
426.6±47.0 °C(Predicted) | [density ]
1.163±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [pka]
pKa 7.5 (Uncertain) |
| Hazard Information | Back Directory | [Uses]
Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768)[1][2]. | [Definition]
ChEBI: Burimamide is a member of imidazoles. | [Biological Activity]
Histamine H 3 /H 2 receptor antagonist (K i values are 0.07, 7.8 and 290 μ M for H 3 , H 2 and H 1 receptors respectively). Displays partial agonist activity in SK-N-MC cells. Produces antinociceptive effects following intraventricular administration (ED 50 = 183 nmol/mouse in hot-plate test). | [References]
[1] Brimblecombe RW, et al. The pharmacology of burimamide and metiamide, two histamine H2-receptor antagonists. Fed Proc. 1976 Jun;35(8):1931-4. PMID:5313
[2] Gupta SC, et al. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem. 2013 Nov 8;288(45):32343-32356. DOI:10.1074/jbc.M113.455188 |
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