| Identification | Back Directory | [Name]
4(1H)-Quinolinone, 8-(2-methylphenoxy)-2-(4-morpholinyl)- | [CAS]
351071-62-0 | [Synonyms]
TGX115
TGX-115
TGX 115
4(1H)-Quinolinone, 8-(2-methylphenoxy)-2-(4-morpholinyl)- | [Molecular Formula]
C20H20N2O3 | [MDL Number]
MFCD12922524 | [MOL File]
351071-62-0.mol | [Molecular Weight]
336.38 |
| Hazard Information | Back Directory | [Uses]
TGX-115 is a cytopermeable and potent PI3-K isomer p110β/p110δ inhibitor (p110β IC50 value of 0.13 μM, p110δ IC50 value of 0.63 μM).TGX-115 is an enzyme that regulates platelet adhesion process and inhibits phosphoinosine 3-kinase. TGX-115 can be used in the study of cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, restenosis, arteriosclerosis and unstable angina[1]. | [Definition]
ChEBI: 8-(2-methylphenoxy)-2-(4-morpholinyl)-1H-quinolin-4-one is an aminoquinoline. | [IC 50]
PI3Kβ: 0.13 μM (IC50); PI3Kδ: 0.63 μM (IC50) | [References]
[1] Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers[J]. ACS medicinal chemistry letters, 2018, 9(4): 300-305. DOI:10.1021/acsmedchemlett.7b00421 |
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