| Identification | Back Directory | [Name]
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride | [CAS]
35108-88-4 | [Synonyms]
Y 6124
Adobiol
bufetolol hydrochloride
Bufetolol-hydrochloride
1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
DL-1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride | [EINECS(EC#)]
252-369-4 | [Molecular Formula]
C18H30ClNO4 | [MOL File]
35108-88-4.mol | [Molecular Weight]
359.888 |
| Hazard Information | Back Directory | [Originator]
Bufetolol,ZYF Pharm | [Definition]
ChEBI: Bufetolol hydrochloride is an aromatic ether. | [Manufacturing Process]
To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2-
(tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1
g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the
ethanol is distilled off. The residue is dissolved in benzene and the solution is
extracted twice with 5% oxalic acid. The aqueous extract is made alkaline
with potassium hydroxide and the isolated oil is extracted with benzene. The
benzene extract is dried over potassium carbonate and the benzene is distilled
off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2-
propanol. The corresponding acid fumarate melts at 128°-132°C. | [Therapeutic Function]
Antiarrhythmic, Beta-adrenergic blocker |
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