| Identification | Back Directory | [Name]
5'-GUANIDINYL-17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5A-EPOXY-3,14-DIHYDROXY-6,7-2',3'-INDOLOMORPHINAN DIHYDROCHLORIDE | [CAS]
351183-88-5 | [Synonyms]
GNTI DIHYDROCHLORIDE
5'-GNTI Dihydrochloride
5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinandihydrochloride
5'-GUANIDINYL-17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5A-EPOXY-3,14-DIHYDROXY-6,7-2',3'-INDOLOMORPHINAN DIHYDROCHLORIDE | [Molecular Formula]
C27H31Cl2N5O3 | [MDL Number]
MFCD06795850 | [MOL File]
351183-88-5.mol | [Molecular Weight]
544.47 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
6''-GNTI Dihydrochloride is a potent, selective κ opioid antagonist. | [in vivo]
5'-Guanidinonaltrindole (5'-GNTI) (0.03-3 mg/kg; s.c.; once) induces scratching in mice[2]. | Animal Model: | Male Swiss-Webster mice[2] | | Dosage: | 0.03, 0.1, 0.3, 1 and 3 mg/kg | | Administration: | Subcutaneous injection, once | | Result: | Induced scratching, the scratch A50 value was calculated to be 0.17 mg/kg. |
| [IC 50]
human μ-opioid receptor: 36.9 nM (Ki); human μ-opioid receptor: 8.49 (pA2) |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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