| Identification | Back Directory | [Name]
PEG18 | [CAS]
351342-04-6 | [Synonyms]
HO-PEG17-OH
OH-PEG17-OH
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48-Hexadecaoxapentacontane-1,50-diol
2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol | [Molecular Formula]
C34H70O18 | [MDL Number]
MFCD28976675 | [MOL File]
351342-04-6.mol | [Molecular Weight]
766.91 |
| Chemical Properties | Back Directory | [Boiling point ]
740.9±55.0 °C(Predicted) | [density ]
1.117±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Solid | [pka]
14.06±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PEG18 contains repeating ethylene glycol subunits and two terminal hydroxyl groups. The hydroxyl groups can participate in reactions to further derivatize the compound. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media. The water solubility properties of the PEG linker are enhanced with longer PEG chains. | [Uses]
HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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