| Identification | Back Directory | [Name]
14(15)-EpEDE | [CAS]
351533-80-7 | [Synonyms]
14(15)-EpEDE
ZXBWLXDDSYHRTE-QGIBGKBZSA-N
14,15-Epoxy-Eicosadienoic Acid
13-(3-pentyl-2-oxiranyl)-8(Z),11(Z)-tridecadienoic acid | [Molecular Formula]
C20H34O3 | [MOL File]
351533-80-7.mol | [Molecular Weight]
322.48 |
| Chemical Properties | Back Directory | [Boiling point ]
458.4±28.0 °C(Predicted) | [density ]
0.970±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be produced, in vivo, by epoxidation of the PUFA by cytochrome P450 epoxygenases. The biological properties of this compound are poorly understood. | [Uses]
(±)14(15)-EpEDE is a a polyunsaturated fatty acid and can be found in DCU (HY-W013989) -treated porcine coronary endothelial cells[1]. | [References]
[1] Fang X, et al. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. J Biol Chem. 2001;276(18):14867-14874. DOI:10.1074/jbc.M011761200 |
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Enzo Biochem Inc
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