| Identification | Back Directory | [Name]
5-(2,4-dichlorophenyl)-3-phenyl-1,2,4-oxadiazole | [CAS]
352346-46-4 | [Synonyms]
BMM 1023
Cpd 1023
Compound 1023
AHR activator 1023
AHR-activator-1023
Branching Morphogenesis Modulator 1023
5-(2,4-dichlorophenyl)-3-phenyl-1,2,4-oxadiazole
1,2,4-Oxadiazole, 5-(2,4-dichlorophenyl)-3-phenyl- | [Molecular Formula]
C14H8Cl2N2O | [MDL Number]
MFCD00760256 | [MOL File]
352346-46-4.mol | [Molecular Weight]
291.13 |
| Hazard Information | Back Directory | [Description]
AHR-activator-1023 is an activator of the aryl hydrocarbon receptor (AHR).It is also a specific modulator of FGF2-induced branching morphogenesis. | [Uses]
AHR activator 1 is an aryl hydrocarbon receptor activator with activity regulating fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. AHR activator 1 prevents the formation of cellular branches by inhibiting AHR signaling. AHR activator 1 also associates with adhesion of dissociated linkers, suggesting the importance of dissociated linkers in the inhibition of branching by AHR agonists. Studies of AHR activator 1 reveal its functional role in mammary gland morphogenesis and play a role in inhibiting FGF-induced invasion[1]. | [References]
[1] Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis |
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