| Identification | Back Directory | [Name]
7-Ketocholesteryl-9-carboxynonanoate | [CAS]
352523-18-3 | [Synonyms]
oxLig-1
7-Ketocholesteryl-9-carboxynonanoate
Cholest-5-en-7-one, 3-[(8-carboxy-1-oxooctyl)oxy]-, (3β)- | [Molecular Formula]
C36H58O5 | [MOL File]
352523-18-3.mol | [Molecular Weight]
570.86 |
| Chemical Properties | Back Directory | [Boiling point ]
662.6±55.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Slightly soluble: 0.1-1 mg/ml | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
oxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is the lipid moiety of oxidized low-density lipoprotein (oxLDL) and is a key ligand for β-glycoprotein I (β(2)-GPI). oxLig-1 causes nuclear translocation by activating the NF-κB pathway. oxLig-1 can be used in the study of atherosclerosis (AS)[1]. | [References]
[1] Huang Z, et al. 7-ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages. Life Sci. 2010 Nov 20;87(19-22):651-7. DOI:10.1016/j.lfs.2010.09.028 |
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