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353486-32-5

353486-32-5 Structure

353486-32-5 Structure
IdentificationBack Directory
[Name]

Ac-hMCH(6-16)-NH2
[CAS]

353486-32-5
[Synonyms]

[Molecular Formula]

C58H97N21O13S3
[MOL File]

353486-32-5.mol
[Molecular Weight]

1392.72
Chemical PropertiesBack Directory
[density ]

1.502±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

9.894±0.15(predicted)
[color ]

White to off-white
[Sequence]

Ac-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-NH2 (disulfide bridge:Cys2-Cys11)
Hazard InformationBack Directory
[Uses]

Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].
[References]

[1] Maria A Bednarek, et al. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. J Biol Chem. 2002 Apr 19;277(16):13821-6. DOI:10.1074/jbc.M200563200
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