| Identification | Back Directory | [Name]
1-(2-Amino-5-hydroxyphenyl)propan-1-one | [CAS]
35364-15-9 | [Synonyms]
aminoketone
2-Amino-5-Hydroxy propiophenone
1-(2-Amino-5-hydroxyphenyl)propan-1-one
1-propanone,1-(2-amino-5-hydroxyhenyl)-
1-(2-Amino-5-hydroxyphenyl)-1-propanone
1-Propanone, 1-(2-amino-5-hydroxyphenyl)- | [Molecular Formula]
C9H11NO2 | [MDL Number]
MFCD16877176 | [MOL File]
35364-15-9.mol | [Molecular Weight]
165.19 |
| Chemical Properties | Back Directory | [Melting point ]
144.5-144.9 °C | [Boiling point ]
363.9±32.0 °C(Predicted) | [density ]
1.195±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.35±0.18(Predicted) | [color ]
Light Yellow to Brown | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-?ring-?modified (RS)?-?camptothecin analogs as antitumor agents. | [Preparation]
Obtained by UV-irradiation of 3-ethyl-2,1-benzisoxazole in 66% sulfuric acid for 90 min at 80–90°
Also prepared from 2-nitro-5-hydroxybenzaldehyde (five steps) or from p-anisidine. |
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