| Identification | Back Directory | [Name]
Endochin | [CAS]
354155-51-4 | [Synonyms]
Endochin
3-heptyl-7-methoxy-2-methyl-1H-quinolin-4-one | [Molecular Formula]
C18H25NO2 | [MDL Number]
MFCD01529682 | [MOL File]
354155-51-4.mol | [Molecular Weight]
287.4 |
| Chemical Properties | Back Directory | [Melting point ]
216-218 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
414.8±45.0 °C(Predicted) | [density ]
1.018±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.07±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Endochin is an experimental antimalarial. Since the 1940s endochin and analogues thereof were known to be causal prophylactic and potent erythrocytic stage agents in avian models. | [Uses]
Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2]. | [IC 50]
Plasmodium | [References]
[1] Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. DOI:10.1073/pnas.1208069109
[2] Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94. DOI:10.1021/jm1007903 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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