| Identification | Back Directory | [Name]
PBOX-15 | [CAS]
354759-10-7 | [Synonyms]
PBOX-15
PBOX15,PBOX 15
PBOX-15 >=98% (HPLC)
Naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-ol, 5-(1-naphthalenyl)-, 4-acetate | [Molecular Formula]
C28H19NO3 | [MDL Number]
MFCD31558509 | [MOL File]
354759-10-7.mol | [Molecular Weight]
417.46 |
| Hazard Information | Back Directory | [Uses]
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells[1][2]. | [References]
[1] Maginn EN, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011 Jan 18;104(2):281-9. DOI:10.1038/sj.bjc.6606035
[2] Mulligan JM, et al. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70(1):60-70. DOI:10.1124/mol.105.021204 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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