| Identification | Back Directory | [Name]
Ac-Asp-Met-Gln-Asp-AMC | [CAS]
355137-38-1 | [Synonyms]
L-α-Asparagine,N-acetyl-L-α-aspartyl-L-methionyl-L-glutaminyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C30H38N6O12S | [MOL File]
355137-38-1.mol | [Molecular Weight]
706.72 |
| Chemical Properties | Back Directory | [Boiling point ]
1274.3±65.0 °C(Predicted) | [density ]
1.429±0.06 g/cm3(Predicted) | [pka]
4.09±0.10(Predicted) | [Sequence]
Ac-Asp-Met-Gln-Asp-{AMC} |
| Hazard Information | Back Directory | [Uses]
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP)[1]. | [IC 50]
Caspase 3 | [References]
[1] Przemys?aw Reszka, et al. Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry. 2008, 19, 1. |
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