| Identification | Back Directory | [Name]
11-DEOXY PROSTAGLANDIN E2 | [CAS]
35536-53-9 | [Synonyms]
11-DEOXY PROSTAGLANDIN E2
CTHZICXYLKQMKI-FOSBLDSVSA-N
9-OXO-15S-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID | [Molecular Formula]
C20H32O4 | [MDL Number]
MFCD00797646 | [MOL File]
35536-53-9.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Boiling point ]
510.3±45.0 °C(Predicted) | [density ]
1.085±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2) | [form ]
A crystalline solid | [pka]
4.75±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory tract smooth muscle with potencies ranging from 5 to 30 times higher than PGF2α . | [Uses]
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions[1][2]. | [Definition]
ChEBI: 11-Deoxy-PGE2 is a prostanoid. | [References]
[1] Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37. DOI:10.1186/s12860-019-0212-5
[2] Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56. DOI:10.1124/mol.59.6.1446 |
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