| Identification | Back Directory | [Name]
N-Desethyl Sunitinib | [CAS]
356068-97-8 | [Synonyms]
SU11662
SU-11662
HY-10873
SU 11662
N-Desethyl Sunitinib
Sunitinib N-Desethyl Imp
SU11662;SU 11662;SU-11662
N-Desethylsunitinib TFA Salt
Sunitinib N-Desethyl Impurity
N-Desethyl Sunitinib (SU-11662)
N-Desethyl Sunitinib
DISCONTINUED
N-Desethyl Sunitinib (Sunitinib Impurity)
(Z)-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
5-[((3Z)-5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide
1H-Pyrrole-3-carboxamide, N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
N-Desethyl Sunitinib/(Z)-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide | [Molecular Formula]
C20H23FN4O2 | [MDL Number]
MFCD18252482 | [MOL File]
356068-97-8.mol | [Molecular Weight]
370.42 |
| Chemical Properties | Back Directory | [Melting point ]
268-270?C | [Boiling point ]
574.4±50.0 °C(Predicted) | [density ]
1.265±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly, Heated), Methanol (Sparingly) | [form ]
Solid | [pka]
11.71±0.20(Predicted) | [color ]
Yellow to Dark Yellow | [InChI]
InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10- | [InChIKey]
LIZNIAKSBJKPQC-GDNBJRDFSA-N | [SMILES]
N1C(/C=C2/C3=C(NC/2=O)C=CC(F)=C3)=C(C)C(C(NCCNCC)=O)=C1C |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
A metabolite of Sunitinib (S820000). | [Biological Activity]
N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor th at is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patientsplasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib. | [storage]
Store at -20°C |
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