| Identification | Back Directory | [Name]
Ani9 | [CAS]
356102-14-2 | [Synonyms]
Ani9
2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide
Acetic acid, 2-(4-chloro-2-methylphenoxy)-, 2-[(2-methoxyphenyl)methylene]hydrazide | [Molecular Formula]
C17H17ClN2O3 | [MDL Number]
MFCD00635759 | [MOL File]
356102-14-2.mol | [Molecular Weight]
332.78 |
| Chemical Properties | Back Directory | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 25 mg/ml | [form ]
powder | [pka]
11.73±0.46(Predicted) | [color ]
white to beige | [InChIKey]
KDALDZRKOBJXIE-UHFFFAOYSA-N | [SMILES]
CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1 |
| Hazard Information | Back Directory | [Description]
Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM). It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner. | [Uses]
(4-Chloro-2-methylphenoxy)-[(2-methoxyphenyl)methylene]hydrazide Acetic Acid inhibits anoctamin1/transmembrane protein 16A, a calcium-activated chloride channel involved in fluid secretion, smooth muscle contraction, nociception and cancer progression. | [Uses]
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules. | [Biochem/physiol Actions]
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma. | [storage]
Store at -20°C | [References]
[1] YOHAN SEO. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.[J]. PLoS ONE, 2016: e0155771. DOI: 10.1371/journal.pone.0155771 |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|