| Identification | Back Directory | [Name]
Tritiozine | [CAS]
35619-65-9 | [Synonyms]
ISF-2001
Tresanil
Tritiozina
Tritiozine
trithiozine
Sulmetozine
Tritiozinum
Tritiozine USP/EP/BP
4-(3,4,5-Trimethoxythiobenzoyl)morpholine
morpholino-(3,4,5-trimethoxyphenyl)methanethione
4-[Thioxo(3,4,5-trimethoxyphenyl)methyl]morpholine
morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanethione
Methanethione, 4-morpholinyl(3,4,5-trimethoxyphenyl)- | [EINECS(EC#)]
252-645-4 | [Molecular Formula]
C14H19NO4S | [MDL Number]
MFCD00866743 | [MOL File]
35619-65-9.mol | [Molecular Weight]
297.37 |
| Chemical Properties | Back Directory | [Melting point ]
141-143° | [Boiling point ]
420.8±55.0 °C(Predicted) | [density ]
1.2461 (rough estimate) | [refractive index ]
1.7500 (estimate) | [form ]
Solid | [pka]
0.88±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1]. | [Definition]
ChEBI: Tritiozine is a member of methoxybenzenes. | [in vivo]
Trithiozine (T) (i. p., oral, i. v.; 50 mg/kg, 200 mg/kg) shows a considerable antisecretory and antiulcer activity on different experimental models in the rats and dogs[1]. | Animal Model: | female Sprague-Dawley rats and male beagle dogs[1] | | Dosage: | 50 mg/kg (rats); 200 mg/kg or 50 mg/kg (dogs) | | Administration: | i. p., single (rats); oral, single or i. v. (dogs) | | Result: | Showed an apparent plasma half-life of about 2.5 h in rats and 1 h in dogs and rapidly metabolized yielding two metabolites and two conjugates. |
| [References]
[1] G. M. Pacifici, et al. Pharmacokinetics and biotransformation, in rats and dogs, of trithiozine, a new antisecretory drug. , 1(3), 141–147. doi:10.1007/bf03189268. |
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