| Identification | Back Directory | [Name]
3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID | [CAS]
3562-99-0 | [Synonyms]
genabil
fel-bis
Icteryl
SC 1749
menbuton
naftobil
genabilin
menbutone
epanaftol
Meng Meng
ido-genabil
genabilicacid
nafto-epatina
MENBUTONE STANDARD
P-METHOXYNAPHTHOYLPROPIONIC ACID
3-(4-methoxy-1-naphthoyl)-propionicaci
3-(4'-METHOXYNAPHTHOYL) PROPIONIC ACID
3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID
beta-(1-methoxy-4-naphthoyl)-propionsaeure
4-keto-4-(4-methoxy-1-naphthyl)butyric acid
4-(4-Methoxy-[1]naphthyl)-4-oxo-butyric acid
1-Naphthalenebutanoic acid, 4-methoxy-g-oxo-
1-Naphthalenebutanoic acid, 4-methoxy-γ-oxo-
4-methoxy-gamma-oxo-1-naphthalenebutanoicaci
acidebeta-(1-methoxy-4-naphthoyl)propionique
1-Methoxy-4-(.beta.-carboxyethylcarbonyl)-naphthalene | [EINECS(EC#)]
222-631-2 | [Molecular Formula]
C15H14O4 | [MDL Number]
MFCD00021539 | [MOL File]
3562-99-0.mol | [Molecular Weight]
258.27 |
| Chemical Properties | Back Directory | [Melting point ]
172-173° | [Boiling point ]
361.52°C (rough estimate) | [density ]
1.2105 (rough estimate) | [refractive index ]
1.4872 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Ethanol (Slightly, Heated) | [form ]
Solid | [pka]
4.44±0.17(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C15H14O4/c1-19-14-8-6-11(13(16)7-9-15(17)18)10-4-2-3-5-12(10)14/h2-6,8H,7,9H2,1H3,(H,17,18) | [InChIKey]
FHGJSJFIQNQBCK-UHFFFAOYSA-N | [SMILES]
C12C=CC=CC1=C(OC)C=CC=2C(=O)CCC(=O)O |
| Hazard Information | Back Directory | [Originator]
Hepalande, Delalande ,W. Germany ,1977 | [Definition]
ChEBI: Menbutone is a butanone. | [Manufacturing Process]
395 parts of (α-methoxynaphthalene and 265 parts of succinic anhydride are dissolved in 8,000 parts of dry benzene at room temperature. The resulting solution is stirred and 710 parts of anhydrous aluminum chloride are added over a period of twenty minutes. During the addition the temperature of the reaction mixture rises to about 60°C to 70°C. After the addition the reaction mixture is stirred for fifteen or twenty minutes at 60°C to 70°C and then refluxed for one hour. The hot reaction mixture is then poured onto a mixture of 5,000 parts of ice and 900 parts of concentrated hydrochloric acid. The benzene is removed by steam distillation and the hot aqueous residue is filtered to remove the insoluble β-(1-methoxy-4-naphthoyl)-propionic acid. The residue of the latter is dried and then dissolved in 16,000 parts of hot water containing 300 parts of sodium carbonate. The hot solution is treated with activated charcoal, filtered while hot, chilled and acidified. The residue of purified acid is collected on a filter, washed with water, and dried at 65°C. A yield of 552 parts of purified β-(1-methoxy)-4-naphthoyl)propionic acid, melting at 172°C to 173°C is obtained. | [Therapeutic Function]
Choleretic | [Synthesis]
Menbutone is prepared by the reaction of succinic acid anhydride and 1-Methoxynaphthalene. The steps are as follows:
15.8 g of 1-methoxynaphthalene and 10.0 g of succinic anhydride were dissolved in 120 mL of dichloromethane,Stir, Cooling to 1 ~ 3 ° C, Divided into three batches of anhydrous aluminum trichloride 15.0 grams, The addition process takes about 20 minutes, The solution was then heated to 35 ± 2 ° C, Insulation reaction 6 hours (5.5 ~ 6.5 hours range), After the reaction is complete, The reaction solution was poured into an ice-water mixture (200 g of ice and 300 g of water) for 30 minutes,Standing, analysiscrystal, Filter, The filtrate was heated and distilled to recover dichloromethane, The cake is the crude of the ketone ketone; And then the crude ketoprofen water as a solvent by 2-3 times recrystallization, Activated carbon decolorization, Demon ketone boutique. The mass of the present product of the compound was 22.3 g, Melting point of 176 ~ 179 ° C, The yield was 86.4%.
 | [storage]
Store at -20°C | [References]
[1] Patent: CN104370734, 2016, B. Location in patent: Paragraph 0016-0018
[2] Helvetica Chimica Acta, 1932, vol. 15, p. 907,914
[3] Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1936, vol. 5/2, p. 73,75
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 2750,2752
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 897,899 |
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