| Chemical Properties | Back Directory | [Boiling point ]
653.9±55.0 °C(Predicted) | [density ]
1.130±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
8.99±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | [Uses]
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation[1]. | [in vitro]
Among them, GKK1032B showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49 μmol·L-1, and a primary mechanistic study revealed that it induced the apoptosis of MG63 cellsvia caspase pathway activation._x000D_
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Reference: Chin J Nat Med. 2022 Jan;20(1):67-73. https://pubmed.ncbi.nlm.nih.gov/35101251/ | [target]
GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. | [References]
[1] Qi X, et, al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019 Apr;72(4):237-240. DOI:10.1038/s41429-019-0144-5
[2] Liu N, et, al. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. Chin J Nat Med. 2022 Jan;20(1):67-73. DOI:10.1016/S1875-5364(21)60108-5 |
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