| Identification | Back Directory | [Name]
UBCS039 | [CAS]
358721-70-7 | [Synonyms]
UBCS039
Pyrrolo[1,2-a]quinoxaline, 4,5-dihydro-4-(3-pyridinyl)- | [Molecular Formula]
C16H13N3 | [MDL Number]
MFCD00206184 | [MOL File]
358721-70-7.mol | [Molecular Weight]
247.29 |
| Chemical Properties | Back Directory | [Boiling point ]
453.9±45.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 125 mg/mL (505.48 mM) | [form ]
Solid | [pka]
4.66±0.12(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines. | [in vitro]
UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.
Western Blot Analysis
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Cell Line:
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Human H1299 cells.
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Concentration:
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75 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.
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Cell Proliferation Assay
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Cell Line:
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Human H1299 cells.
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Concentration:
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100 μM.
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Incubation Time:
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48 and 72 hours.
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Result:
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Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
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| [target]
| Target | Value | SIRT6
(Cell-free assay) | 38 μM(EC50) |
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