| Identification | Back Directory | [Name]
26,27-Dinorergost-5-ene-3β,24-diol | [CAS]
35882-85-0 | [Synonyms]
SGE-201
26,27-Dinorergost-5-ene-3β,24-diol
24,24-dimethyl-cholene-(5)-diol-(3β.24)
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-5-methylhexan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C26H44O2 | [MDL Number]
MFCD28386299 | [MOL File]
35882-85-0.mol | [Molecular Weight]
388.63 |
| Hazard Information | Back Directory | [Description]
SGE-201 is a potent allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 is an analogue of an endogenous oxysterol. bSGE-201 increased the actions of memantine and ketamine on phasic excitatory post-synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE-201 accelerated the re-equilibration of blockers during voltage jumps. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult. | [Uses]
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors (NMDARs), demonstrating significant neuroprotective effects by enhancing NMDAR-mediated responses while differing in action among various blockers in neuronal networks. | [References]
[1] The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors DOI:10.1523/JNEUROSCI.2619-13.2013 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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