35960-33-9

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35960-33-9 Structure

Identification	Back Directory
[Name] ASIALOGANGLIOSIDE-GM2
[CAS] 35960-33-9
[Synonyms] GG3 ASIALO GM2 Glycolipid GA2 Ganglioside GA2 GA2 GANGLIOSIDE gangliosides (Gls) Tay-Sachs globoside CERAMIDE TRIHEXOSIDE ASIALOGANGLIOSIDE-GM2 Glycosphingolipid GA2 Ganglioside GM2, Asialo GANGLIOTRIOSYL CERAMIDE ganglio-n-triaosylceramide ASIALOGANGLIOSIDE GM2, BOVINE Ganglioside GM2 Asialo Mixture Asialoganglioside GM₂ ASIALOGANGLIOSIDE GM2, FROM BOVINE BRAIN GA2 Ganglioside, Gangliotriosyl ceramide Asialoganglioside-GM2 from bovine brain,GA2 Ganglioside, Gangliotriosyl ceramide
[Molecular Formula] C56H104N2O18
[MDL Number] MFCD00131129
[MOL File] 35960-33-9.mol
[Molecular Weight] 1093.43

Chemical Properties	Back Directory
[storage temp. ] −20°C
[solubility ] Chloroform:Methanol:Water (2:1:0.1): Soluble
[form ] lyophilized powder

Safety Data	Back Directory
[WGK Germany ] 3

Hazard Information	Back Directory
[Description] Ganglioside G_M2 asialo (asialo- G_M2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M₂. Asialo-G_M2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients. Asialo-G_M2 mixture contains ganglioside G_M2 asialo molecular species with fatty acyl chains of variable lengths. [Matreya, LLC. Catalog No. 1512]
[Uses] Ganglioside GM2, Asialo is a semisynthetic ganglioside.
[General Description] Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
[Biochem/physiol Actions] Degraded form of Asialoganglioside-GM1 ganglioside.

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