| Identification | Back Directory | [Name]
H-TRP-GLU-OH | [CAS]
36099-95-3 | [Synonyms]
WE
G3335
TRP-GLU
L-TRP-GLU
H-TRP-GLU-OH
TRP-GLU CRYSTALLINE
PPARγ Antagonist III,G3335
L-TRYPTOPHYL-L-GLUTAMIC ACID
L-Glutamic acid, L-tryptophyl-
PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem | [Molecular Formula]
C16H19N3O5 | [MDL Number]
MFCD00037964 | [MOL File]
36099-95-3.mol | [Molecular Weight]
333.34 |
| Chemical Properties | Back Directory | [Melting point ]
>163°C(dec.) | [Boiling point ]
720.7±60.0 °C(Predicted) | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
White solid | [pka]
3.02±0.10(Predicted) | [color ]
white to off-white | [Water Solubility ]
water: 30mg/mL | [Sensitive ]
Light Sensitive | [InChI]
1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1 | [InChIKey]
PWIQCLSQVQBOQV-AAEUAGOBSA-N | [SMILES]
[nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2 |
| Hazard Information | Back Directory | [Uses]
Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone in a dose-dependent manner (IC50=31.9μM). | [Definition]
ChEBI: Trp-Glu is a dipeptide formed from L-tryptophan and L-glutamic acid residues. It has a role as a metabolite. | [Biological Activity]
kd = 8.34 μmg3335 is a pparγ antagonist.the peroxisome proliferator-activated receptor gamma (ppargamma) is a key therapeutic drug target for several conditions, such as inflammation, diabetes, hypertension, dyslipidemia, and cancer. | [in vitro]
biacore 3000 study based on the surface plasmon resonance technique found that g3335 exhibited a highly specific binding affinity against ppargamma and was able to block rosiglitazone, a potent ppargamma agonist, in the stimulation of the interaction between the ppargamma ligand-binding domain (lbd) and rxralpha-lbd. moreover, the yeast two-hybrid assays indicated that g3335 had strong antagonistic activity in perturbing rosiglitazone in the promotion of the ppargamma-lbd-cbp interaction. in addition, g3335 could competitively bind to ppargamma against 0.1 microm rosiglitazone to repress reporter-gene expression [1]. | [in vivo]
in a previous study, the effect of rosiglitazone was examined on spinal cord injury (sci) in rats. the animals were randomly divided into vehicle group, rosiglitazone treated group, and g3335 treated group. locomotor function recovery was evaluated. results showed that compared with the vehicle groups, the rosiglitazone could significantly ameliorate locomotor recovery, reduce nf-κb expression, and increase the proliferation of endogenous npcs. in addition, when the ppar-γ antagonist g3335 was applied, such effects were abolished [2]. | [IC 50]
PPARγ: 8 μM (Kd) | [References]
[1] ye, f. ,zhang, z.s.,luo, h.b., et al. the dipeptide h-trp-glu-oh shows highly antagonistic activity against pparγ: bioassay with molecular modeling simulation. chembiochem 7, 74-82 (2006).
[2] meng, q. q.,liang, x.j.,wang, p., et al. rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. neuroscience letters 503, 191-195 (2011). |
|
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Ontores Biotech
|
| Telephone: |
0571-88760729 18072970094 |
| Website: |
www.ontoresinc.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|