| Identification | Back Directory | [Name]
3H-Pyrazol-3-one, 4-[[(1,3-benzodioxol-5-ylmethyl)amino]methylene]-2-(2-benzothiazolyl)-5-[[(4-chlorophenyl)thio]methyl]-2,4-dihydro- | [CAS]
361198-09-6 | [Synonyms]
3H-Pyrazol-3-one, 4-[[(1,3-benzodioxol-5-ylmethyl)amino]methylene]-2-(2-benzothiazolyl)-5-[[(4-chlorophenyl)thio]methyl]-2,4-dihydro- | [Molecular Formula]
C26H19ClN4O3S2 | [MOL File]
361198-09-6.mol | [Molecular Weight]
535.04 |
| Hazard Information | Back Directory | [Description]
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP90α. | [Uses]
F0911-7667 is a SIRT1 activator that induces autophagic cell death in U87MG and T98G cells by activating the AMPK-mTOR-ULK complex. CWR tripeptide was also identified as a SIRT1 activator that reduced p53 acetylation in IMR32 neuroblastoma cells and protected cells from cell death induced by Aβ fragments[1]. | [References]
[1] A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate |
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