| Identification | More | [Name]
N-Benzyl-4-piperidone | [CAS]
3612-20-2 | [Synonyms]
1-BENZYL-4-OXOPIPERIDINE
1-BENZYL-4-PIPERIDINONE
1-BENZYL-4-PIPERIDONE
1-BENZYLPIPERIDIN-4-ONE
1-(PHENYLMETHYL)-4-PIPERIDINONE
1-(PHENYLMETHYL)-4-PIPERIDONE
4-PIPERIDINONE, 1-(PHENYLMETHYL)-
BENZYL-4-PIPERIDONE
BENZYLPIPERIDONE-4
LABOTEST-BB LT00232987
N-BENZYL-4-PIPERIDONE
N-BENZYLPIPERIDONE
1-Benzylpiperidone
4-Piperidone, 1-benzyl-
4-Piperidone,1-benzyl-
N-Benzyl-4-piperidinone
N-Benzyl-4-piperidon
N-Benzylpiperidin-4-one
N-Benzylpiperidinone
1-Benzyl-4-Pipridine | [EINECS(EC#)]
222-782-4 | [Molecular Formula]
C12H15NO | [MDL Number]
MFCD00006192 | [Molecular Weight]
189.25 | [MOL File]
3612-20-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to straw coloured oily liquid | [Boiling point ]
134 °C7 mm Hg(lit.)
| [density ]
1.021 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.079-0.15Pa at 20-25℃ | [refractive index ]
n20/D 1.541(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
12g/l | [form ]
Oily Liquid | [pka]
7.07±0.20(Predicted) | [color ]
Clear colorless to straw | [Specific Gravity]
1.021 | [Water Solubility ]
12 g/L (20 ºC) | [BRN ]
128556 | [InChI]
1S/C12H15NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2 | [InChIKey]
SJZKULRDWHPHGG-UHFFFAOYSA-N | [SMILES]
O=C1CCN(CC1)Cc2ccccc2 | [LogP]
2.1 at 20℃ and pH9 | [CAS DataBase Reference]
3612-20-2(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Piperidinone, 1-(phenylmethyl)-(3612-20-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact.
R22:Harmful if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29333999 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Benzylamine-->Methyl propionate-->4,4-Piperidinediol hydrochloride | [Preparation Products]
4,5,6,7-TETRAHYDRO-2-METHYLFURO[3,2-C]PYRIDINE-->1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL-->1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)-->1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4S)-(9CI)-->4-(1-Pyrrolidinyl)piperidine-->1-Benzyl-4-hydroxypiperidine-->(1-BENZYLPIPERIDIN-4-YLIDENE)ACETIC ACID ETHYL ESTER-->1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE-->4-(3-Trifuoromethyl)phenyl-4-piperidinol-->N-Boc-2-piperidone-->2-Oxa-8-azaspiro[4.5]decane-->Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate-->4-(2-Aminoethyl)-1-benzylpiperidine-->4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE-->4-METHYLENEPIPERIDINE-->TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-4-CARBOXYLATE |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to straw coloured oily liquid | [Uses]
A substituted piperidine as pesticide | [Reactions]
As an important organic compound, N-Benzyl-4-piperidone could be used to synthesize many organic compounds. There are four ways to synthesize 1-benzylpiperidine-4-carbaldehyde using it as the raw material.
The first method involves the Wittig reaction of (methoxymethyl) triphenylphosphonium chloride with N-benzyl-4-piperidone, followed by hydrolysis of the resulting enol ether.
In another method, trimethylsilyl diazomethane is condensed with N-benzyl-4-piperidone, followed by hydrolysis to obtain the final product.
In a third route, N-benzyl-4-piperidone is treated with trimethyloxosulfonium iodide to produce the corresponding epoxide. The epoxide is then rearranged in the presence of magnesium bromide etherate, resulting in 1-benzylpiperidine-4-carbaldehyde with high yields.
In 2007, a patent described the Darzens condensation of N-benzyl-4-piperidone with ethyl chloroacetate, followed by decarboxylation[1].
 | [Synthesis]
1-Benzyl-4-piperidone was synthesized with benzylamine and methyl acrylate as raw materials via 1,4-addition, Dieckmann condensation and hydrolysis decarboxylafion reactions. Add 150 mL of anhydrous toluene and 2.8 g of metallic sodium to a 250 mL dry three-necked flask, stir and heat to reflux. Add 1 mL of anhydrous methanol, then slowly drop 28 g of N.N-bis(β-propionate methyl ester) benzylamine. After adding N.N-bis(β-propionate methyl ester), benzylamine is completed, reflux for 6 h. During the reflux process, the stirring speed needs to be increased, and 100 ml of anhydrous toluene is added to the reaction vessel in batches. Stop reflux, cool to room temperature, extract the mixture with 150 mL of 25% (mass fraction) hydrochloric acid solution, and reflux in an oil bath for 5 h until there is no colour change in the FeCl3 solution test, indicating that the reaction is over. Cool the reaction mixture, add 35% NaOH solution while stirring to neutralize to about pH=8.5, extract with ethyl acetate (100 ml×3), combine the ethyl acetate layers, wash with saturated NaCl solution, and dry over anhydrous magnesium sulfate. Ethyl acetate was recovered by distillation, and the remaining material was distilled under reduced pressure to obtain 14.8 g of 1-benzyl-4-piperidone with a yield of 78.4%. The product was a light yellow oily liquid.
| [Purification Methods]
If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.] | [References]
[1] Chavakula R, et al. Industrially Viable Preparation ofN-Benzyl-4-formylpiperidine, a Key Intermediate of Donepezil. Organic Preparations and Procedures International, 2013; 45: 168-170. |
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