| Identification | Back Directory | [Name]
hydracarbazine | [CAS]
3614-47-9 | [Synonyms]
TH-2151
hydracarbazine
Hidracarbazina
Hydracarbazinum
6-Hydrazino-3-pyridazinecarboxamide
6-hydrazinopyridazine-3-carboxamide
6-hydrazinylpyridazine-3-carboxamide
3-Pyridazinecarboxamide, 6-hydrazinyl-
6-hydrazinylidene-1,6-dihydropyridazine-3-carboxamide | [EINECS(EC#)]
222-788-7 | [Molecular Formula]
C5H7N5O | [MDL Number]
MFCD00867322 | [MOL File]
3614-47-9.mol | [Molecular Weight]
153.14 |
| Chemical Properties | Back Directory | [Melting point ]
249-250 °C (decomp) | [Boiling point ]
361.8±25.0 °C(Predicted) | [density ]
1.71±0.1 g/cm3(Predicted) | [pka]
12.21±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Hydracarbazine is a pyridazine. Hydracarbazine can effectively lower blood pressure, it can be used for the research of high blood pressure[1][2]. | [Definition]
ChEBI: Hydracarbazine is a heteroarene and an aromatic amide. | [in vivo]
Hydracarbazine (1-4 mg/kg; i.v. once) induced in the dog, cat and rabbit hypotension by peripheral vasodilation, showed no inhibitory action on vasomotor centers and decreased the hypertensive effects of adrenaline, noradrenaline, 5-hydroxytryptamine, pituitrin, and splanchnic nerve stimulation[1].
Hydracarbazine (15-18 mg/kg; p.o. once daily) prevents the increased blood pressure and heart rate, reduces the renal histol and reduces the hypertensive syndrome with a combination of pempidine in high arterial pressure rats[2]. | [References]
[1] Schmitt H, et al. Pharmacological study of a new hypotensor with a long duration of action: 1-hydrazino-4-carboxamidopyridazine (1325). Journal de Physiologie. 1992 52:525-36.
[2] Ghaye-Roquet J, et al. [Prevention of experimental hypertension in the rat by prolonged administration of a combination of antihypertensive agents]. Arch Int Pharmacodyn Ther. 1967 Mar;166(1):65-78. PMID:6034330 |
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