| Identification | Back Directory | [Name]
columbamine | [CAS]
3621-36-1 | [Synonyms]
Columbamin
Dehydroisocorypalmine
Columbamine (Columbamin
5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol
5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium
Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy- | [Molecular Formula]
[C20H20NO4]+. | [MDL Number]
MFCD01546522 | [MOL File]
3621-36-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
280-282℃ (methanol ) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: soluble | [form ]
Powder | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Chemical Properties]
Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits. | [Uses]
Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects. | [Definition]
ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound. | [Biological Activity]
Columbamine is a quaternary isoquinoline alkaloid extracted from plants. | [in vivo]
Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
| Animal Model: | Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | Administered to experimental mice for 23 days | | Result: | Decreased the tumor volumes in a dose-dependent manner. |
| [IC 50]
CYP3A4: 30.6 μM (IC50) |
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