| Identification | Back Directory | [Name]
GSI-18 | [CAS]
362653-62-1 | [Synonyms]
GSI-18
2-Thiophenesulfonamide, N-[(6R,9S)-5,6,7,8,9,10-hexahydro-6,9-methanobenzocycloocten-11-yl]-, rel- | [Molecular Formula]
C17H19NO2S2 | [MOL File]
362653-62-1.mol | [Molecular Weight]
333.47 |
| Chemical Properties | Back Directory | [Boiling point ]
505.985±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.356±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
10.610±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling[1]. | [References]
[1] Mullendore, et al. "Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer." Clinical Cancer Research 15.7 (2009): 2291-2301. DOI:10.1158/1078-0432.CCR-08-2004 |
|
|