| Identification | Back Directory | [Name]
1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate | [CAS]
362703-34-2 | [Synonyms]
Methyl 4-cyanopiperidine-4-carboxylate hydrochloride
1-Boc-4-cyano-4-piperidinecarboxylic acid methyl ester
1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate
O1-tert-butyl O4-methyl 4-cyanopiperidine-1,4-dicarboxylate
1,4-Piperidinedicarboxylic acid, 4-cyano-, 1-(1,1-dimethylethyl) 4-methyl ester | [Molecular Formula]
C13H21N2O4 | [MDL Number]
MFCD18711601 | [MOL File]
362703-34-2.mol | [Molecular Weight]
269.317 |
| Chemical Properties | Back Directory | [Boiling point ]
377.1±42.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
-4.10±0.40(Predicted) | [Appearance]
Off-white to light brown Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of methyl N-Boc-4-cyanopiperidine-4-carboxylate from the compound (CAS: 362703-33-1) and di-tert-butyl dicarbonate was as follows: piperidine (640 mg, 2.11 mmol) from reaction (24a), di-tert-butyl dicarbonate (500 mg, 2.3 mmol) and a catalytic amount of palladium hydroxide were dissolved in ethyl acetate ( 10 mL). The hydrogenation reaction was carried out under hydrogen atmosphere at 1 atmosphere. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was subsequently concentrated to afford the target product methyl N-Boc-4-cyanopiperidine-4-carboxylate (566 mg, 100% yield). Mass spectral analysis showed (M + H)+ = 269. | [References]
[1] Patent: US2004/72802, 2004, A1. Location in patent: Page/Page column 46 |
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