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365-08-2

365-08-2 Structure

365-08-2 Structure
IdentificationBack Directory
[Name]

thymidine 5'-(tetrahydrogen triphosphate)
[CAS]

365-08-2
[Synonyms]

5'-TTP
Deoxy-TTP
5-Methyl-dUTP
dTTP.Free Acid
2'-Deoxythymidine triposphate
Thymidine-5''-triphosphoric acid
thymidine 5'-(tetrahydrogen triphosphate)
thymidine 5'-(tetrahydrogen triphosphate) USP/EP/BP
[hydroxy-[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxy-phosphoryl]oxyphosphonic acid
[EINECS(EC#)]

206-669-7
[Molecular Formula]

C10H17N2O14P3
[MDL Number]

MFCD05881427
[MOL File]

365-08-2.mol
[Molecular Weight]

482.17
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,2-8°C
[density ]

1.922±0.06 g/cm3(Predicted)
[form ]

Liquid
[pka]

0.80±0.50(Predicted)
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Deoxythymidine-5'-triphosphate-13C10 (dTTP-13C10) dilithium is 13C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
[Definition]

ChEBI: DTTP is a thymidine phosphate having a triphosphate group at the 5'-position. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine 2'-deoxyribonucleoside 5'-triphosphate and a thymidine phosphate. It is a conjugate acid of a dTTP(3-).
[References]

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202. DOI:10.1111/j.1365-2362.1975.tb00446.x
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