| Identification | Back Directory | [Name]
4-methylhistamine | [CAS]
36507-31-0 | [Synonyms]
C025566
4-methylhistamine
5-Methylhistamine
4-Methylhistamine hydride
5-Methyl-1H-imidazole-4-ethanamine
5-(2-Aminoethyl)-4-methylimidazole
1H-Imidazole-5-ethanamine,4-methyl-
1H-Imidazole-4-ethanamine, 5-methyl-
2-(5-Methyl-1H-imidazol-4-yl)-ethylamine
2-(4-Methyl-1H-imidazol-5-yl)ethan-1-amine | [Molecular Formula]
C6H11N3 | [MDL Number]
MFCD01721795 | [MOL File]
36507-31-0.mol | [Molecular Weight]
125.17 |
| Hazard Information | Back Directory | [Uses]
4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2]. | [Definition]
ChEBI: An aralkylamino compound that is histamine bearing a methyl substituent at the 5 position on the ring. | [References]
[1] Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. DOI:10.1016/j.imbio.2014.10.014
[2] Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17. DOI:10.1111/sji.12420 |
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