| Identification | Back Directory | [Name]
2-Hydroxy-6-(2-naphthalen-2-yl-ethyl)-benzoic acid | [CAS]
365542-77-4 | [Synonyms]
2-Hydroxy-6-[2-(2-naphthyl)ethyl]benzoic acid
2-Hydroxy-6-(2-naphthalen-2-yl-ethyl)-benzoic acid
Benzoic acid, 2-hydroxy-6-[2-(2-naphthalenyl)ethyl]- | [Molecular Formula]
C19H16O3 | [MDL Number]
MFCD12546734 | [MOL File]
365542-77-4.mol | [Molecular Weight]
292.33 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [color ]
Off-white to light brown | [InChI]
1S/C19H16O3/c20-17-7-3-6-15(18(17)19(21)22)11-9-13-8-10-14-4-1-2-5-16(14)12-13/h1-8,10,12,20H,9,11H2,(H,21,22) | [InChIKey]
GGVFBUYNEPBFQT-UHFFFAOYSA-N | [SMILES]
OC1=C(C(O)=O)C(CCC2=CC3=C(C=CC=C3)C=C2)=CC=C1 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Sm4 is a novel SOX18 blocker, suppressing genes downstream of the gene for Sox18 and interferring with vascular development, showing anti-cancer and anti-metastatic effects. | [Uses]
Sm4 is a SOX18 inhibitor. Sm4 shows SOX18-DNA binding inhibitory activity. Sm4 selectively affects SOX18 transcriptional output in vitro. Sm4 blocks SoxF transcriptional activity in vivo. Sm4 can be used for cancer metastasis and vascular cancers research[1]. | [References]
[1] Mathias FRANCOIS. Inhibitors of sox18 protein activity for treating angiogenesis- and/or lymphangiogenesis-related diseases. Patent, WO2018112545A1. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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