| Identification | Back Directory | [Name]
1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- | [CAS]
366487-89-0 | [Synonyms]
1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- | [Molecular Formula]
C23H40N2O4 | [MOL File]
366487-89-0.mol | [Molecular Weight]
408.57 |
| Hazard Information | Back Directory | [Uses]
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2]. | [IC 50]
Caspase-8; Caspase-9; Caspase 3 | [References]
[1] Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20(3):392-9. DOI:10.1038/sj.leu.2404084
[2] Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003. |
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