| Identification | Back Directory | [Name]
MPP+ IODIDE | [CAS]
36913-39-0 | [Synonyms]
4-phenylpyridin-1-ium iodide
1-methyl-4-phenylpyridin-1-ium
MPP+ IODIDE ISO 9001：2015 REACH
1-methyl-4-phenyl-pyridiniuiodide
N-Methyl-4-phenylpyridinium iodide
1-Methyl-4-phenylpyridin-1-iuM iodide
Pyridinium, 1-methyl-4-phenyl-, iodide
MPP+ iodide,1-Methyl-4-phenylpyridinium iodide
MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX | [Molecular Formula]
C12H12IN | [MDL Number]
MFCD00055096 | [MOL File]
36913-39-0.mol | [Molecular Weight]
297.135 |
| Chemical Properties | Back Directory | [Melting point ]
166-168 °C | [storage temp. ]
desiccated | [solubility ]
0.1 M HCl: soluble
| [form ]
solid
| [color ]
yellow
| [Water Solubility ]
H2O: 10mg/mL, clear | [InChI]
InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1 | [InChIKey]
RFDFRDXIIKROAI-UHFFFAOYSA-M | [SMILES]
C1(C=C[N+](C)=CC=1)C1=CC=CC=C1.[I-] |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25-36/37/38-25 | [Safety Statements ]
26-36-45 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
UU6580000
| [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. | [General Description]
1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. | [Biochem/physiol Actions]
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP. |
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