| Identification | Back Directory | [Name]
Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) | [CAS]
369638-68-6 | [Synonyms]
pyrazin-2-yL
2-Boc-Amino-5-methylpyrazine
2-N-Boc-aMino-5-Methylpyrazin
1,1-diMethylethyl ester (9CI)
N-Boc-2-amino-5-methylpyrazine
tert-butyl N-(5-Methylpyrazin-2-yl)carbaMate
CarbaMic acid,N-(5-Methyl-2-pyrazinyl)-, 1,1-diMethylethyl ester
Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) | [EINECS(EC#)]
200-589-5 | [Molecular Formula]
C10H15N3O2 | [MDL Number]
MFCD09907674 | [MOL File]
369638-68-6.mol | [Molecular Weight]
209.245 |
| Chemical Properties | Back Directory | [Boiling point ]
268.8±40.0 °C(Predicted) | [density ]
1.154±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [pka]
11.63±0.70(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
5-Methylpyrazine-2-carboxylic acid (13.81 g, 0.1 mol), tert-butanol (95 mL, 1 mol), triethylamine (27.9 mL, 0.2 mol) and diphenylphosphoryl azide (30.27 g, 0.11 mol) were dissolved in 300 mL of toluene. The reaction mixture was heated to reflux temperature for 8 hours. Upon completion of the reaction, the product was purified by silica gel column chromatography with petroleum ether-ethyl acetate (20:1, v/v) as eluent to afford 15.2 g of N-Boc-2-amino-5-methylpyrazine as a pale yellow solid in 72.7% yield. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3751 - 3754
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 18, p. 4136 - 4142
[3] Patent: EP2781508, 2014, A1. Location in patent: Paragraph 0153
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[5] Patent: WO2011/90738, 2011, A2. Location in patent: Page/Page column 45 |
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| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|