| Identification | Back Directory | [Name]
8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione | [CAS]
370871-42-4 | [Synonyms]
7030B-C5
8-(2-hydroxyethylamino)-7-[(3-methoxyphenyl)methyl]-1,3-dimethylpurine-2,6-dione
8-[(2-Hydroxyethyl)amino]-7-(3-methoxybenzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
1H-Purine-2,6-dione, 3,7-dihydro-8-[(2-hydroxyethyl)amino]-7-[(3-methoxyphenyl)methyl]-1,3-dimethyl- | [Molecular Formula]
C17H21N5O4 | [MOL File]
370871-42-4.mol | [Molecular Weight]
359.38 |
| Hazard Information | Back Directory | [Uses]
7030B-C5 is a PCSK9 inhibitor (IC50=1.61 μM). 7030B-C5 can significantly reduce plasma cholesterol and triglyceride (TG) levels in vivo and slow the progression of atherosclerosis. 7030B-C5 can be used in the study of cardiovascular diseases[1]. | [References]
[1] Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. DOI:10.1038/s41392-023-01690-3 |
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