| Identification | Back Directory | [Name]
N,N′-Diisoprophyl phosphordiamide fluoride | [CAS]
371-86-8 | [Synonyms]
mipafox
Isopestox
Pestox XV
Mipafox [ISO]
DIISOPROPYLFLUORPHOSPHORAMIDE
BIS(ISOPROPYLAMIDO)FLUOROPHOSPHATE
Bisisopropylaminofluorophosphine oxide
Fluorobis(isopropylamino)phosphine oxide
N,N'-diisopropylphosphorodiamidic fluoride
N,N′-Diisoprophyl phosphordiamide fluoride
N,N'-Diisopropyl-diamido-phosphorsaeure-fluorid
N-[fluoro-(isopropylamino)phosphoryl]propan-2-amine
N,N'-Diisopropil-fosforodiammido-fluoruro [Italian]
mipafox NN'- di-isopropylphosphorodiamidic fluoride
[fluoro-(isopropylamino)phosphoryl]-isopropyl-amine
Phosphorodiamidic fluoride, N,N'-bis(1-methylethyl)-
N,N'-Diisopropyl-diamido-fosforzuur-fluoride [Dutch]
N-[fluoro-(propan-2-ylamino)phosphoryl]propan-2-amine
Fluorure de N,N'-diisopropyle phosphorodiamide [French] | [EINECS(EC#)]
206-742-3 | [Molecular Formula]
C6H16FN2OP | [MDL Number]
MFCD00801119 | [MOL File]
371-86-8.mol | [Molecular Weight]
182.18 |
| Chemical Properties | Back Directory | [Melting point ]
65° | [Boiling point ]
125.5°C | [density ]
1.2 g/cm3(Temp: 25 °C) | [form ]
solid | [pka]
-2.71±0.70(Predicted) | [Water Solubility ]
74.07g/L(temperature not stated) | [Henry's Law Constant]
3.3×103 mol/(m3Pa) at 25℃, HSDB (2015) | [EPA Substance Registry System]
Mipafox (371-86-8) |
| Hazard Information | Back Directory | [Uses]
Insecticide. | [Hazard]
Cholinesterase inhibitor. | [Definition]
ChEBI: Mipafox is a phosphoramide. | [Production Methods]
Commercial production information for mipafox is not available in open literature. However, based on its structure and on general industrial practice for phosphorodiamidic fluorides, commercial production would have involved preparing a diisopropylphosphorodiamidic precursor, typically via controlled amination of a phosphoryl intermediate, followed by conversion to the fluorophosphorodiamidate using a fluorinating agent under tightly regulated conditions due to the compound’s extreme toxicity and reactivity. | [Mechanism of action]
Selective and systemic. Acetylcholinesterase (AchE) inhibitor. | [Pesticide Type]
Insecticide; Acaricide |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
39/26/27/28 | [Safety Statements ]
13-45 | [RIDADR ]
2783 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of F-, NOx, and POx. See also PARATHION and FLUORIDES. | [Hazardous Substances Data]
371-86-8(Hazardous Substances Data) | [Toxicity]
Formerly used as a
systemic insecticide. Its use was discontinued because of
severe delayed neuropathy hazard in humans. The oral
LD50/LC50 in rabbits is 100 mg/kg. Toxic action is as a neurotoxicant
with both acute and delayed actions, acting as a
cholinesterase inhibitor (acute toxicity) and as a neurotoxic
esterase inhibitor (possibly linked to delayed toxicity).
Symptoms in humans are typical anticholinesterase symptoms.
Therapy is supportive as well as atropine sulfate and
2-PAM. |
|
| Company Name: |
Matrix Scientific
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| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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